Activation of rabbit blood platelets by anandamide through its cleavage into arachidonic acid
Open Access
- 5 April 2000
- journal article
- Published by Wiley in FEBS Letters
- Vol. 471 (1) , 12-16
- https://doi.org/10.1016/s0014-5793(00)01359-4
Abstract
Anandamide (ANA), a cannabinoid receptor ligand, stimulated platelet aggregation at concentrations similar to those of arachidonic acid (AA). The aggregating effect of ANA was inhibited by aspirin bu...Keywords
This publication has 38 references indexed in Scilit:
- Enzymatic Synthesis of Anandamide, an Endogenous Cannabinoid Receptor Ligand, through N-Acylphosphatidylethanolamine Pathway in Testis: Involvement of Ca2+-Dependent Transacylase and Phosphodiesterase ActivitiesBiochemical and Biophysical Research Communications, 1996
- Anandamide hydroxylation by brain lipoxygenase:metabolite structures and potencies at the cannabinoid receptorBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1995
- The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamideFEBS Letters, 1995
- Lipoxygenase-catalyzed oxygenation of arachidonylethanolamide, a cannabinoid receptor agonistBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1995
- Formation and inactivation of endogenous cannabinoid anandamide in central neuronsNature, 1994
- Platelet secretory phospholipase A2 fails to induce rabbit platelet activation and to release arachidonic acid in contrast with venom phospholipases A2Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1994
- Molecular characterization of a peripheral receptor for cannabinoidsNature, 1993
- Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid ReceptorScience, 1992
- Structure of a cannabinoid receptor and functional expression of the cloned cDNANature, 1990
- Oxygenation of phosphatidylcholine by human polymorphonuclear leukocyte 15-lipoxygenaseBiochemical and Biophysical Research Communications, 1985