Experimental treatment of chronic Trypanosoma cruzi infection in mice with 2‐n‐propylquinoline

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Abstract
It was reported previously that 2‐n‐propylquinoline was active against the epimastigote form of Trypanosoma cruzi. The effects of oral treatments with benznidazole and 2‐n‐propylquinoline were evaluated in Balb/c mice infected with T. cruzi chronically. The reference drug and 2‐n‐propylquinoline were administered 60 days post‐infection for 30 days at 25 mg/mL. At 35 days post‐treatment, the serological tests (ELISA) of the 2‐n‐ propylquinoline‐treated mice were significantly different from the controls (p = 0.01) and the benznidazole‐treated mice (p = 0.03), while this was not the case at 85 days post‐treatment. These results are encouraging for continuing the investigation of other analogues of 2‐n‐propylquinoline in experimental chronic Chagas' disease. Copyright © 2001 John Wiley & Sons, Ltd.