Primaquine analogues that are potentanti-Trypanosoma cruziagents in a mouse model

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Abstract
Seventy-seven primaquine analogues were evaluated for their effectiveness in reducing the parasitaemias in female albino mice (aged 4–6 weeks) which had been infected with a Brazilian strain of Trypanosoma cruzi 15 days earlier. Of the analogues tested, 23 were more effective than the reference drug, nifurtimox, and one was > 14-fold as effective as the standard and almost four times as active as primaquine itself. Certain members of the series tested warrant further evaluation.