THE EFFECTS ON THE CARDIOVASCULAR SYSTEM OF FLUIDS ADMINISTERED INTRAVENOUSLY IN MAN. I. STUDIES OF THE AMOUNT AND DURATION OF CHANGES IN BLOOD VOLUME

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Abstract
The effects on the hematocrit, plasma protein concn. and blood volume of fluids injected intraven. were studied in patients not suffering from shock, marked dehydration. or cardiac or renal insufficiency. After injections of from 500 to 1500 cc. of physiological saline solution, 5% glucose solution or 5% glucose in physiological saline soln., at rates of 6-71 cc. per min., the hematocrit and the serum protein concn. were always lowered. The plasma and blood volumes, measured by the "Evans Blue" dye method, and obtained by calculation from the hematocrit and protein changes, were increased invariably after such injections. The greatest and most persistent blood volume increases occurred when the larger amts. of the hypertonic solution (5% glucose in physiological saline) were given at the more rapid rates of injection. In 8 cases given 1000 cc. of 5% glucose in physiological saline intraven. at rates of 32 to 71 cc. per min. the average increase in blood volume at the end of injection was 700 cc. The blood volumes in such cases remained appreciably increased for approximately 2 hrs. after injection. The findings have been discussed in reference to edema and pulmonary congestion.