Acetylenic Amides. I. Synthesis of N-Substituted-2-propynamides
- 1 July 1993
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 23 (14) , 2003-2010
- https://doi.org/10.1080/00397919308009860
Abstract
The efficient synthesis of N-substituted-2-propynamides was accomplished by three methods; the reaction of amines with either the N-hydroxysuccinimide ester or mixed anhydride of propiolic acid, or by the interaction of lithiotrimethylsilylacetylene with isocyanates followed by desilation with fluoride.Keywords
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