INDUCTION OF CELLULAR DNA SYNTHESIS BY POLYOMA VIRUS
- 1 February 1965
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 53 (2) , 403-410
- https://doi.org/10.1073/pnas.53.2.403
Abstract
Crowded cultures of mouse kidney cells have a very low rate of DNA synthesis, and very low activities of the enzymes involved in DNA synthesis. After infection with polyoma virus, both the enzyme activities and the rate of DNA synthesis markedly increase. It is of special interest that the DNA synthesized in the infected cells is predominantly cellular. The ability of the virus to stimulate the synthesis of cellular DNA may be related to its tumorigenic property.Keywords
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