Organic acids and calcium in hyperventilation

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Abstract
Voluntary hyperventilation in male human subjects produced a rise in plasma citric and lactic acid concentrations and a fall in inorganic phosphorus concentration. The maximum changes occurred 12—25 min after the end of 15—20 min of hyperventilation. Arterial-venous differences indicate that peripheral tissue was the source of the increased concentration of organic acids. The results suggest that hyperventilation produces a change in intermediary metabolism and that the formation of organic acid-calcium complexes decrease the calcium activity at the cell membrane. Submitted on December 21, 1960