PHARMACOKINETIC STUDIES OF OXALATE IN MAN

  • 1 January 1979
    • journal article
    • research article
    • Vol. 16  (5) , 395-398
Abstract
The observation of the plasma concentrations after rapid i.v. administration of inulin and 14C-oxalate to 6 normal and 1 hyperoxaluric subjects allowed estimations of the half-life of elimination of oxalate (mean 91.7 min), volume of distribution of oxalate (mean = 32.5 l), calculation of the miscible oxalate pool (mean 3.7 mg), of the plasma oxalate concentration (mean = 11.1 .mu.g/100 ml), of the oxalate clearance (252 ml/min), and the determination of the oxalate turnover rate (0.027 mg/min). The 14C-oxalate/inulin clearance ratio was 2.44 implying an additional excretion mechanism apart from glomerular filtration. Inasmuch as 97.2% of the administered tracer were recovered unchanged in urine, nonrenal loss of oxalate was not an appreciable factor. The data of 1 hyperoxaluric patient were compared with those of the healthy subjects.

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