The composition of diphtheria toxin— Antitoxin floccules
- 14 January 1930
- journal article
- research article
- Published by The Royal Society in Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
- Vol. 106 (741) , 1-19
- https://doi.org/10.1098/rspb.1930.0008
Abstract
The ultra-violet absorption curve was employed in an attempt to determine the composition of diphtheria toxin-antitoxin precipitates. The effect of varying concentrations of non-specific proteins on the amount of precipitate was also observed. As a result of their investigations, the authors conclude that the floccules consist almost entirely of denatured pseudo-globulin derived from the antiserum. The amount of precipitate obtained from a balanced mixture of toxin and antitoxin is largely independent of various conditions, such as amount of non-specific protein. It is believed that antitoxin actually is pseudoglobulin.Keywords
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