Mianserin, maprotiline and the electroencephalogram.
- 1 April 1983
- journal article
- clinical trial
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 15 (S2) , 255S-259S
- https://doi.org/10.1111/j.1365-2125.1983.tb05873.x
Abstract
1 EEGs were recorded from patients with depressive illness before and after four weeks of treatment with mianserin, maprotiline or placebo. 2 Visual analysis of the records showed a small but statistically significant increase in frequency of beta activity in the mianserin group. 3 One subject taking maprotiline developed spike and wave discharges but had no convulsive seizures. 4 The findings do not support those of previous studies. It seems that changes seen in the EEG early after treatment are not sustained for four weeks.Keywords
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