Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.
- 1 February 1980
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 77 (2) , 919-923
- https://doi.org/10.1073/pnas.77.2.919
Abstract
Cloning and nucleotide sequence determination suggest that the rearranged .gamma.1-chain gene in a .gamma.1-chain-producing [mouse] myeloma appears to be formed by the recombination between the 5'' flanking regions of the .gamma.1- and .mu.-chain genes of undifferentiated cells. The recombination site is distinct from the putative J [joining] region and is a novel region called the S region. The previous model, which explains H-chain class switching by 2 or more successive recombination events, was extended.Keywords
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