CONCENTRATIONS OF PROSTAGLANDIN-D2, PROSTAGLANDIN-E2, PROSTAGLANDIN-F2-ALPHA, PROSTAGLANDIN-6-KETO-F1-ALPHA AND THROMBOXANE-B2 IN SYNOVIAL-FLUID FROM PATIENTS WITH INFLAMMATORY JOINT DISORDERS AND OSTEOARTHRITIS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 43  (2) , 89-96
Abstract
Concentrations of PG[prostaglandin]D2, PGE2, PGF2.alpha., 6-keto-PGF1.alpha. and TX[thromboxane]B2 in synovial fluid from patients with rheumatoid arthritis (RA), Reiter''s disease (RD), acute gouty arthritis (GA) and osteoarthritis (OA) were measured by radioimmunoassay. PGE2 was the most predominant prostanoid (pg/ml; mean .+-. SEM [standard error of the mean]): RA 887 .+-. 85, RD 870 .+-. 71, GA 1064 .+-. 155 and OA 665 .+-. 71. In patients with OA, lower mean levels of all the prostanoids were found than compared to the other groups of patients. Only in patients with RA could a slight correlation between PGD2/PGF2.alpha., PGE2/PGF2.alpha. and PGE2/6-keto-PGF1.alpha. be demonstrated. No significant correlations between the leukocyte cell counts in the synovial fluid and the prostanoid concentrations were found. In patients with RA, developing recurrent knee joint effusions within 4 wk after the 1st sampling, significantly lower levels of PGE2 and TXB2 were found in the recurrent samples (PGE2 792 .+-. 183; TXB2 179 .+-. 33)than compared with the original samples (PGE2 984 .+-. 146; TXB2 239 .+-. 32).