PHARMACOKINETICS OF AZATHIOPRINE UNDER HEMODIALYSIS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 14  (4) , 298-302
Abstract
Due to the retarded elimination of azathioprine and its metabolites immunosuppressive therapy creates certain problems during acute or chronic renal failure. For this reason the pharmacokinetics of azathioprine and its metabolites were studied in patients with chronic renal failure. Elimination during 8 h of hemodialysis amounted to 45%, which is only slightly less than the elimination in the urine of normal persons over a period of 24 h. Because the dialysis of azathioprine and its metabolites was similar to that for uric acid, effective elimination through hemodialysis was possible. The dose of azathioprine for effective immunosuppressive therapy can probably be maintained under simultaneous hemodialysis.

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