EFFECT ON RESPIRATION IN MIDPONTINE ANIMAL OF CHEMICAL INHIBITION OF FACILITATORY SYSTEM

Publisher Website
Google Scholar
Abstract
When admd. to 21 decerebrate and vagotomized dogs showing apneustic breathing, Myanesin reversibly abolished apneusis and re-established normal respiration. This supports the view that the medulla is inherently capable of generating a normal respiratory periodicity and that apneusis results from the action on the medulla of more rostral centers which cause inspiratory over-activity and distortion of the medullary rhythm. Since Myanesin, in the doses employed, is known to have a predominant depressant action on the reticular facilitatory system, it may be inferred that the apneustic center is related to this system.
Keywords