Detecting transcriptionally active regions using genomic tiling arrays
Open Access
- 1 March 2006
- journal article
- method
- Published by Springer Nature in Genome Biology
- Vol. 7 (7) , R59
- https://doi.org/10.1186/gb-2006-7-7-r59
Abstract
We have developed a method for interpreting genomic tiling array data, implemented as the program TranscriptionDetector. Probed loci expressed above background are identified by combining replicates in a way that makes minimal assumptions about the data. We performed medium-resolution Anopheles gambiae tiling array experiments and found extensive transcription of both coding and non-coding regions. Our method also showed improved detection of transcriptional units when applied to high-density tiling array data for ten human chromosomes.Keywords
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