Immunohistochemical identification of the corticotropin releasing factor (CRF)-containing nerve fibers in the pig hypophysis, with special reference to the relationship between CRF and posterior lobe hormones.

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Abstract
Immunoperoxidase histochemical investigations on pig hypophysis show that CRF immunoreactive nerve terminals are distributed among the blood vessels in the posterior lobe, particularly in its proximal part adjacent to the intermediate lobe. CRF immunoreactive nerve fibers are also seen in the intermediate lobe. The distribution of the CRF-containing nerve in the posterior lobe was similar to that of the vasopressin-containing nerve terminals. The functional significance of the presence of CRF-containing nerve fibers representing a new component of the hypothalamo-hypophyseal neurosecretory system is discussed.