Cyclin A: Function and expression during cell proliferation
- 1 January 1995
- book chapter
- Published by Springer Nature
- Vol. 1, 115-123
- https://doi.org/10.1007/978-1-4615-1809-9_9
Abstract
Cyclin A is a key regulatory protein which, in mammalian cells, is involved in both S phase and the G2/M transition of the cell cycle through its association with distinct cdks. Several lines of evidence have also implicated cyclin A in carcinogenesis. Our review concentrates on the role of cyclin A in S phase, in the S/G2 transition and in human carcinogenesis; it will also discuss the transcriptional regulation of cyclin A gene.Keywords
This publication has 57 references indexed in Scilit:
- Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinaseCell, 1994
- Promoter-Selective Transcriptional Defect in Cell Cycle Mutant ts13 Rescued by hTAF II 250Science, 1994
- Effect of Tumor Suppressors on Cell Cycle-Regulatory Genes: RB Suppresses p34cdc2 Expression and Normal p53 Suppresses Cyclin A ExpressionExperimental Cell Research, 1994
- p21 is a universal inhibitor of cyclin kinasesNature, 1993
- Localization of Cyclin A at the Sites of Cellular DNA ReplicationExperimental Cell Research, 1993
- Cyclin A is required in S phase in normal epithelial cellsBiochemical and Biophysical Research Communications, 1992
- Cell Cycle Control of DNA Replication by a Homologue from Human Cells of the p34
cdc2
Protein KinaseScience, 1990
- Universal control mechanism regulating onset of M-phaseNature, 1990
- Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREBNature, 1988
- The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune responseImmunology Today, 1988