The liver and fat metabolism

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Abstract
A study was made of the variations in the liver lipids of rats (a) receiving a meal of a diet consisting of sucrose 40, caseinogen 20, fat 40 and cholesterol 2 parts, but free from choline, and (b) receiving a meal as under (a) with the addition of choline chloride, 2 parts. The 3% of phosphatide fell to a min. value at the 7th hr., and returned to normal at 13 hrs. In the corresponding animals which received choline these phosphatide decreases were less than 1/3 as great. Both series of animals showed no change in liver neutral fat for about 4 hrs., then a rapid increase to the 10th hr., followed by a return towards normal at the end of 13 hrs. In the livers of animals which received choline, the fat was uniformly lower than that of the control series. The iodine values of the total fatty acids decreased in both groups during the 1st 10 hrs. The livers of animals in both series showed no change in the free cholesterol content; on the other hand, the amount of cholesteryl esters in the livers increased in linear fashion to the end of the experiment. Choline has no marked effect in preventing this increase.

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