A new aspect of gastric metaplasia in Crohn's disease: Bidirectional (foveolar and pyloric) differentiation in so‐called ‘pyloric metaplasia’ in the ileum

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Abstract
Wucus‐secreting cells found at the site of lieac ulceration in Crohn's disease have been described as ‘pyloric metaplasla’. Using mucin‐histochemical methods and Immunohistochemical stainings for KI‐67 antigen and foveolar‐type much (M1) of the stomach, the charecteristics of this type of metaplasia were studied in surgically resected lieac specimens from two Japanese patients with Crohn's disease. Not only pyloric‐type cells but also foveolar‐type cells were demonstrated; often displaying an organold growth of the normal stomach mucosa. Stem cells of the ileac crypt may differentiate potentially to intestinal‐, pyloric‐ and also to foveolar‐type cells. The term ‘pyloric metaplasia’ is not appropriate and ‘gastric metaplasia’ should be used when describing this type of metaplasia.