XXXIX Studies of Papilloma of the Larynx

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Abstract
Tissue cultures of laryngeal papilloma appear to grow more rapidly and with greater ease than cultures of embryonic or other adult tissues, either benign or malignant. The influence of endocrine factors on the growth of laryngeal papilloma is demonstrated by the effect of puberty, pregnancy and direct topical application of hormonal agents. Viral studies with human laryngeal papilloma tissues have indicated the presence of a species-specific virus capable of producing growth of tissue cultures with regrowth on as many as eight passages. Serologic studies suggest that the cytopathogenic agent in the tissue cultures is a human virus capable of producing compliment-fixing antibodies. Animal innocula-tions of papilloma suspensions, egg cultures and tissue cultures of laryngeal papillomata were all negative, indicating an absence of other viruses and that the papilloma growth agent is species specific. Autogenous vaccines have been prepared for and administered to eight patients with laryngeal papillomatosis; four adults and four children. The series is still too small to draw definite conclusions, but some encouraging results seem to have been obtained.

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