FLOW-CYTOMETRY OF BREAST-CARCINOMA .3. POSSIBLE ALTERED KINETICS IN AXILLARY LYMPH-NODE METASTASES
- 1 January 1982
- journal article
- research article
- Vol. 4 (4) , 275-278
Abstract
The cell cycle distribution of human mammary carcinoma was determined by flow cytometry in 21 cases and compared with that of the same tumor concurrently metastatic in regional lymph nodes. The percentage of S-phage cells in the nodal metastasis as compared to the primary tumor was significantly lower in estrogen-binding-positive tumors than in estrogen-binding-negative tumors. Since we do not have evidence of clonal evolution in the metastases, it is possible that there is a local inhibitory effect of the lymph node on tumor cell proliferation in the case of some estrogen-binding-positive tumors.This publication has 6 references indexed in Scilit:
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