Soluble Nef antigen of HIV‐1 is cytotoxic for human CD4+ T cells
Open Access
- 9 September 1996
- journal article
- Published by Wiley in FEBS Letters
- Vol. 393 (1) , 93-96
- https://doi.org/10.1016/0014-5793(96)00859-9
Abstract
We have previously shown that Nef‐gene 10 fusion protein induces marked growth arrest of human primary CD4+ T cells. Here, in vitro cytostatic and cytotoxic activities of human immunodeficiency virus type 1 (HIV‐1) Nef against CD4+ T cells were extensively investigated. Growth of human CD4+ cells was inhibited significantly just by the addition of purified full‐length Nef to cultures. When Nef was cross‐linked by anti‐Nef antibodies, it became very cytocidal for CD4+ T cells. A high percentage of sera from HIV‐1‐infected individuals contained soluble Nef. Thus, soluble Nef in vivo may play an important role in immunodysfunction of CD4+ T lymphocytes in HIV‐1 infection.Keywords
This publication has 21 references indexed in Scilit:
- Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120Nature, 1995
- Induction of Apoptosis in Uninfected Lymphocytes by HIV-1 Tat ProteinScience, 1995
- Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infectionNature, 1995
- HIV-1 nef leads to inhibition or activation of T cells depending on its intracellular localizationImmunity, 1994
- Expression of human immunodeficiency virus type 1 Nef antigen on the surface of acutely and persistently infected human T cellsVaccine, 1993
- Importance of the nef gene for maintenance of high virus loads and for development of AIDSCell, 1991
- Complete nucleotide sequence of the AIDS virus, HTLV-IIINature, 1985
- Isolation of Lymphocytopathic Retroviruses from San Francisco Patients with AIDSScience, 1984
- Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDSScience, 1984
- Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Science, 1983