HEPATIC LIPOGENESIS IN THE DIABETICHYPOPHYSECTOMIZED (HOUSSAY) RAT1

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Abstract
IT WAS demonstrated earlier that, provided carbohydrate in the form of glucose or starch is available in large amounts to hypophysectomized rats, hepatic lipogenesis, as judged by the conversion of acetate carbon to fatty acids, does not differ significantly from that observed in normal rats (1). Our findings offered no support for the view that hepatic lipogenesis is accelerated in the absence of pituitary hormones (2, 3, 4). Indeed, when hypophysectomized rats were fed a stock diet adequate in all respects, but containing whole ground wheat as the major carbohydrate source, lipogenesis and cholesterogenesis in their livers were below normal (1). The results obtained by Hill et al. (1) emphasize the need for a careful evaluation of the nutritional state of the hypophysectomized animal before ascribing a metabolic effect to the removal of the anterior pituitary gland. It is now generally agreed that the diabetic animal has lost, to a considerable extent, its capacity to form fat from carbohydrate (5, 6).

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