Acquired immunological tolerance of foreign cells is impaired by recombinant interleukin 2 or vitamin A acetate.

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Abstract
The susceptibility of newborn mice to the inception of tolerance after exposure to antigen is associated with their deficiency in the production of endogenous interleukin 2 (IL-2). A solid and long-lasting state of tolerance induced by the i.v. injection into newborn CBA mice of lymphoid cells from (CBA .times. C47BL/10ScSn)F1 hybrids can be brought to an end by the administration of exogenous IL-2 or by supplementing an otherwise normal diet with vitamin A acetate, the effect of which is to increase the proportion of the moiety of the T-cell population that produces IL-2. Certain nonspecific stimuli can influence whether immunological tolerance is maintained.