ROLE OF CARBON DIOXIDE IN THE DIMORPHISM OF COCCIDIOIDES IMMITIS

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Abstract
Coccidioides immitis strain M-11 was grown in the spherule form in liquid shake culture with insignificant development of mycelium when the inoculum of spherules was 2.0 mg dry wt. per ml. Reduction of the inoculum to 0.2 mg per ml resulted in the appearance of substantial amounts of mycelium. The spherule form could be maintained at the lower inoculum by incubating the culture in air supplemented with 10% CO2. A similar effect was seen in the improved conversion of arthro-spores to spherules in the presence of added CO2.

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