Analogues of [3H] Chloramphenicol for Photoaffinity Labeling
- 1 January 1979
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 360 (1) , 721-724
- https://doi.org/10.1515/bchm2.1979.360.1.721
Abstract
The synthesis of [3H]chloramphenicol and its erythro-diastereoisomer with specific activities of 1.25 Ci/mmol and the further transformation of the [3H]chloramphenicol to a series of azido and diazo-substituted derivatives are described. The antibiotic activity of the compounds was considered insufficient for their use as photoaffinity labels.This publication has 3 references indexed in Scilit:
- Correction of prior estimate of the biological activity of an N-trifluoroacetyl analog of D-threo-chloramphenicol relative to chloramphenicolJournal of Medicinal Chemistry, 1977
- A photo-induced reaction of chloramphenicol with E.coli ribosomes: Covalent binding of the antibiotic and inactivation of peptidyl transferaseBiochemical and Biophysical Research Communications, 1974
- Studies on the Mechanism of Action of ChloramphenicolPublished by Elsevier ,1963