Evidence for Existence of Inactive Arterial Renin-Like Enzyme in the Rat

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Abstract
Inactive renin-like enzyme(s) in the arterial wall of the rat are converted to active renin-like enzyme in vitro by either “acid activation” (dialysis to pH 3.3 followed by dialysis to pH 7.4) or “protease-induced activation” (trypsin, α-chymotrypsin and glandular kallikrein). The molecular weights of the inactive reninlike enzyme(s) before trypsin activation were estimated to be about 68,000, 44,000, 36,000 and 30,000 by column chromatography. These findings may offer a new aspect for the role of the arterial renin-angiotensin system in the local control of vascular tone by interconversion of the inactive to the active renin-like enzymes in the arterial wall.