Hydrodynamics and mass transfer in Aspergillus niger fermentations in bubble column and loop bioreactors
- 1 September 1989
- journal article
- research article
- Published by Wiley in Biotechnology & Bioengineering
- Vol. 34 (6) , 731-740
- https://doi.org/10.1002/bit.260340602
Abstract
The influence of Aspergillus niger broth rheology, bioreactor geometry, and superficial gas velocity on the volumetric liquid phase oxygen transfer coefficient (kLaL), riser gas holdup (εGR), and circulating liquid velocity (uLR) was studied in a bubble column (BC) and two external‐circulation‐loop airlift (ECLAL) bioreactors. The results are compared to those of previous studies on homogeneous fluids and in particular with a recent study on non‐Newtonian carboxymethylcellulose (CMC) solutions conducted in the same contactors used for the A. niger fermentations. As expected from the CMC‐based studies, in the heterogeneous broths of A. niger εGR, kLaL, and uLR decreased with increasing broth apparent viscosity; εGR and kLaL decreased with increasing downcomer‐to‐riser cross‐sectional area ratio, Ad/Ar, whereas uLR increased with increasing Ad/Ar. Gas holdup data in the airlift fermentations of A. niger were well predicted by the CMC‐based correlation. However, the CMC‐based correlations produced conservative estimations of kLaL and overestimates of uLR compared to the observed values in the A. niger broths.This publication has 22 references indexed in Scilit:
- Mass transfer studies of external-loop airlifts and a bubble columnAIChE Journal, 1989
- External‐circulation‐loop airlift bioreactors: Study of the liquid circulating velocity in highly viscous non‐Newtonian liquidsBiotechnology & Bioengineering, 1988
- The specific interfacial area in external-circulation-loop airlifts and a bubble column-I. Aqueous sodium sulphite solutionChemical Engineering Science, 1987
- The Influence of "Slip" on Rheological Measurements on a Mycelial Broth of Aspergillus nigerAnnals of the New York Academy of Sciences, 1987
- Viscous media in tower bioreactors: Hydrodynamic characteristics and mass transfer propertiesBioprocess and Biosystems Engineering, 1987
- The specific interfacial area in external-circulation-loop airlifts and a bubble column-II. Carboxymethyl cellulose/sulphite solutionChemical Engineering Science, 1987
- Oxygen mass transfer into aerated CMC solutions in a bubble columnBiotechnology & Bioengineering, 1982
- Review of Methods for the Measurement of Oxygen Transfer in Microbial SystemsPublished by Elsevier ,1982
- Comparison of measured and calculated oxygen solubilities in fermentation mediaBiotechnology & Bioengineering, 1981
- Heat Transfer in Aerated Tower Filled with Non-Newtonian LiquidIndustrial & Engineering Chemistry Process Design and Development, 1977