Lactic Acid Production and Adrenaline Reversal in Experiments on Isolated Smooth Muscle

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Abstract
In experiments on isolated muscle preparations from rabbit stomach adrenaline had a contracting effect and increased the lactic acid content. Lactic acid was determined with an enzymatic method. After treatment with dibenamine, the preparations were relaxed by adrenaline. The lactic acid production remained unchanged. Adrenaline reversal after dibenamine was interpreted as a selective inhibition by dibenamine of the contracting effect of adrenaline, following which the relaxing and lactic acid stimulating action was evidence.