Abnormal segregation and sex ratio and reduced litter size associated with the siren phenotype in mice

1 April 1973

journal article
Published by Wiley in Teratology

Vol. 7 (2) , 195-198
https://doi.org/10.1002/tera.1420070212

Abstract

Abnormal segregation ratios in +/srn intercrosses found at term were due to prenatal loss of siren embryos. Litters without sirens were smaller than those with sirens; litters with sirens were smaller than control litters. There was a significant excess of prenatal resorptions in +/srn intercross litters compared with control litters, suggesting reduced reproductive fitness of +/srn females. The abnormal siren sex ratio at term may have been due to excessive prenatal loss of siren females.

Keywords

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