beta-Endorphin: cross tolerance to and cross physical dependence on morphine.
- 1 November 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (11) , 4187-4189
- https://doi.org/10.1073/pnas.73.11.4187
Abstract
The effects of .beta.-endorphin on the antinociceptive responses and abrupt withdrawal jumping in morphine-dependent mice were studied. Mice were rendered morphine dependent by implantation of a morphine pellet (75 mg base) for 3 days. The analgesic response to .beta.-endorphin decreased after morphine pellet implantation, as evidenced by an 8-fold increase in the median antinociceptive dose. A similar increase in the median antinociceptive dose of morphine was found. In small doses (0.09-.17 .mu.g/mouse), .beta.-endorphin suppressed abrupt withdrawal jumping. Met[methionine]-enkephalin, even in high doses (200 .mu.g/mouse), did not suppress abrupt withdrawal jumping.This publication has 11 references indexed in Scilit:
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