Genetics of global gene expression
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- 1 November 2006
- journal article
- review article
- Published by Springer Nature in Nature Reviews Genetics
- Vol. 7 (11) , 862-872
- https://doi.org/10.1038/nrg1964
Abstract
A new field of genetic analysis of global gene expression has emerged in recent years, driven by the realization that traditional techniques of linkage and association analysis can be applied to thousands of transcript levels measured by microarrays. Genetic dissection of transcript abundance has shed light on the architecture of quantitative traits, provided a new approach for connecting DNA sequence variation with phenotypic variation, and improved our understanding of transcriptional regulation and regulatory variation.Keywords
This publication has 116 references indexed in Scilit:
- All possible modes of gene action are observed in a global comparison of gene expression in a maize F 1 hybrid and its inbred parentsProceedings of the National Academy of Sciences, 2006
- An integrative genomics approach to infer causal associations between gene expression and diseaseNature Genetics, 2005
- A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease riskNature, 2005
- Genetic analysis of genome-wide variation in human gene expressionNature, 2004
- Evolutionary changes in cis and trans gene regulationNature, 2004
- Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factorsNature Genetics, 2003
- Detection of regulatory variation in mouse genesNature Genetics, 2002
- Variation in gene expression within and among natural populationsNature Genetics, 2002
- Dissecting the architecture of a quantitative trait locus in yeastNature, 2002
- Understanding quantitative genetic variationNature Reviews Genetics, 2002