The inclusion of diflunisal by α- and β-cyclodextrins. A 19F Nuclear magnetic resonance and spectrophotometric study
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases
- Vol. 83 (9) , 2697-2703
- https://doi.org/10.1039/f19878302697
Abstract
The complexation of the diflunisal anion (DF) by α-cyclodextrin (αCD) and β-cyclodextrin (βCD) in aqueous solution at pH 7.00 at 298.2 K has been studied by 19F n.m.r. and u.v.-visible spectroscopy. The formation of 1:1 and 1:2 inclusion complexes by βCD proceeds through the two equilibria: [graphic omitted] characterised by K1=(1.81±0.20)× 105 dm3 mol–1 and K2=(3.07±0.25)× 103 dm3 mol–1. In the presence of αCD only the DF·αCD complex, characterised by K1= 17.0±0.9 dm3 mol–1, is detected.Keywords
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