The Effect of Duodenal Infusion of Bile on Plasma VIP, GIP, and Secretin and on Duodenal Bicarbonate Secretion

Abstract
Nine healthy young male students were studied before, during and after a 10 min period of duodenal infusion of 6 g dried cattle bile dissolved in 75 ml distilled water to iso-osmolarity and pH adjusted to pH 7.0. Plasma vasoactive intestinal polypeptide (VIP), gastric inhibitory polypeptide (GIP) and duodenal bicarbonate secretion increased significantly, whereas plasma secretin showed a late but not significant tendency to rise after the bile infusion.