Hemolysin Production in Irradiated Mice Given Spleen or Bone-Marrow Homogenate

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Abstract
Circulating hemolysin reached peak titers on the 5th day following a single injection of a standard suspension of sheep erythrocytes. Titers gradually dropped for the succeeding 5 days (slope= 0.126, t1/2=2.38 days). Hemolysin production was suppressed in other groups of mice exposed to 450r (LD4%, 28 days) X-rays over the whole body until the 4th week. From the 4th week the titers gradually improved but recovery was not complete even by the 8th week after irradiation. Recovery of the production of hemolysin in irradiated mice receiving bone-marrow or spleen cell homogenate occurred at the same rate as in littermate control mice exposed to 450r. The time required for the production of peak titers following a single immunizing injection was comparable in the irradiated mice with or without homogenate despite the salutary effect of the marrow or spleen injections on hemotopoiesis.