Ansamitocin analogs from a mutant strain of Nocardia I. Isolation of the mutant,fermentation and antimicrobial properties.
- 1 January 1981
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 34 (5) , 489-495
- https://doi.org/10.7164/antibiotics.34.489
Abstract
A mutant having a high ability to produce ansamitocins was derived from a dnacin-producing strain, Nocardia sp. no. C-14482 (N-1001), by treatment with ethidium bromide. Mutant N-1231 produced ansamitocins P-3 and P-4 as major components but was deficient in its ability to produce dnacins. Strain N-1231 also produced 15 novel ansamitocin analogs as minor components. These analogs showed no activity against prokaryotic microorganisms. The results of determining the activity inhibiting cilia regeneration of deciliated Tetrahymena pyriformis suggest that hydroxylation of C15, C20 and the acyl moiety at C3 of ansamitocins may cause marked reduction of their antitubulinic activities; demethylation of -NCH3 at C18 slightly affected their activites.This publication has 2 references indexed in Scilit:
- Dnacins, new antibiotics. I. Producing organism, fermentation, and antimicrobial activities.The Journal of Antibiotics, 1980
- The sporulation system of Bacillus subtilis as the basis of a multi-gene mutagen screening testMutation Research/Environmental Mutagenesis and Related Subjects, 1976