Studies on the Survival of Incompatible Cells in Patients with Hypogammaglobulinemia

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Abstract
1. Four adult patients are described whose sera showed a complete lack of gamma globulin by paper electrophoresis. 2. All four patients might have been considered "universal recipients" because of the absence of isohemagglutinins on routine laboratory tests. 3. Weak isohemagglutinins were detectable in the sera from three of the four subjects when the sensitivity of the in vitro test was increased. 4. Following intravenous administration of 4 ml. of ABO-incompatible cells, red cell survival was shortened in all of the patients, with a wide range of half-survival times from none of the 4 hypogammaglobulinemic patients in the present series could be categorized as "universal recipients."