THE RELATION OF NEUTRAL FAT TO LACTESCENCE OF SERUM 1

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Abstract
A variety of clear and lactescent sera obtained from patients having elevated serum lipids was analyzed for total fatty acids, free and total cholesterol, phospholipid and neutral fat before and after the removal of insoluble lipids by ultra-centrifugation at 18,000 RPM (about 20,000 g) for 1 hour. When neutral fat increased above 20 meq/l the serum was invariably lactescent. The insoluble material causing the lactescence was composed chiefly of neutral fat but it also included considerable quantities of cholesterol and phospholipid. As neutral fat rose increasingly larger proportions of cholesterol and phospholipid were found in the insoluble form, suggesting that these fractions were dissolved in the particulate neutral fat and thereby withheld from the aqueous phase of serum.