Immunocytochemical Reaction of Serum of Patients with Hepatic Diseases With Hepatic Structures.

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Abstract
Sera from patients with various hepatic diseases, lupus erythematosus and hospital controls were studied by the indirect Coons fluorescent antibody technic with cryostat sections of human livers, hearts and kidneys and various rat and rabbit organs. Two types of circulating reacting substances were demonstrated: one noted in patients with primary billiary cirrhosis and malignant hepatitis bound nuclei without species or organ specificity; the other occurring in a variety of hepatic diseases reacted with the cytoplasm of ductule cells. The former was influenced by steroid therapy while the latter was not. The antigenic material in the ductular cell possibly is a muco- or lipo-protein which may also be present in bile.