LIPID PEROXIDES AND ALPHA-TOCOPHEROL IN RAT STREPTOZOTOCIN-INDUCED DIABETES-MELLITUS

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Abstract
Lipid peroxides and .alpha.-tocopherol were measured in rats with streptozotocin-induced diabetes. In sera and livers of diabetic rats, the lipid peroxides increased but .alpha.-tocopherol decreased. To study the effect of vitamin E deficiency in the diabetic state, diabetes was induced in rats maintained on a vitamin E deficient diet. Serum lipid peroxides increased greatly but .alpha.-tocopherol decreased. Lipid peroxides and .alpha.-tocopherol increased in the liver of vitamin E deficient states. In the liver, vitamin E deficient diabetic rats had lower lipid peroxide levels but higher .alpha.-tocopherol levels than vitamin E deficient non-diabetic rats. The decrease of .alpha.-tocopherol might be due to consumption as an antioxidant as lipid peroxides increased in sera and livers. The decrease of lipid peroxides in the liver could play an important part of the increase in serum lipid peroxides.