Effects of Alloxan-Induced Diabetes on Dopaminergic Receptors in Rat Striatum and Anterior Pituitary
- 1 January 1985
- journal article
- research article
- Published by S. Karger AG in Hormone Research
- Vol. 21 (2) , 95-101
- https://doi.org/10.1159/000180032
Abstract
The binding of [3H]-spiroperidol after 4 weeks of hyperglycemia was determined in the rat striatum and anterior pituitary. Alloxan-induced diabetes increased the number of dopaminergic binding sites in the striatum but not in the anterior pituitary. The interaction of metoclopramide with striatal dopaminergic receptors was slightly modified, while that of dopamine, bromocriptine and haloperidol was unaffected. These results suggest that chronic hyperglycemia exerts selective effects on nigrostriatal dopaminergic system in the rat.Keywords
This publication has 8 references indexed in Scilit:
- Interaction of Sulpiride with Human Pituitary Dopaminergic Receptors Is Sodium Dependent1Hormone Research, 1984
- Dopamine Receptor Binding Is Increased in Diabetic RatsScience, 1981
- Sodium-Dependent Interaction of Benzamides with Dopamine Receptors in Rat and Dog Anterior Pituitary GlandsNeuroendocrinology, 1981
- Glucose Suppresses Basal Firing and Haloperidol-Induced Increases in the Firing Rate of Central Dopaminergic NeuronsScience, 1980
- Dehydration Selectively Increases Dopamine Synthesis in Tuberohypophyseal Dopaminergic NeuronsNeuroendocrinology, 1980
- Observations on the function of the dopaminergic nerves innervating the pituitary glandNeuroscience, 1978
- REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐IJournal of Neurochemistry, 1966
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951