Chromosomal Aberrations Induced by Hyponitrite and Hydroxylamine Derivatives2
- 1 March 1964
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 32 (3) , 667-679
- https://doi.org/10.1093/jnci/32.3.667
Abstract
Hydroxylamine and certain of its derivatives induced fragmentations, translocations, and rearrangements of the metaphase chromosomes of mouse embryo and Chinese hamster cells. The compounds included: N-methylhy-droxylamine; N-hydroxyurethan, a carcinogen; hydroxyurea, which exerts a leukopenic action in patients with chronic granulocytic leukemia; N-hydroxyaminoacetic acid, derived from the tumor-inhibitor hadacidin; and hyponitrous acid, which can be formed in situ from hydroxylamines. Since these agents induced main-chain cleavage of isolated deoxyribonucleic acid (DNA) in solution, it is believed that the observed morphological aberrations are due to a direct attack on the DNA of the chromosome.Keywords
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