A Novel Integrin-activated Pathway Forms PKB/Akt- stimulatory Phosphatidylinositol 3,4-Bisphosphate via Phosphatidylinositol 3-Phosphate in Platelets
Open Access
- 1 January 1998
- journal article
- Published by Elsevier
- Vol. 273 (1) , 13-16
- https://doi.org/10.1074/jbc.273.1.13
Abstract
No abstract availableKeywords
This publication has 18 references indexed in Scilit:
- Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase BScience, 1997
- Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase BαCurrent Biology, 1997
- Inositol Polyphosphate 4-Phosphatase Is Inactivated by Calpain-mediated Proteolysis in Stimulated Human PlateletsJournal of Biological Chemistry, 1997
- Calpains are involved in phosphatidylinositol 3′,4′‐bisphosphate synthesis dependent on the αIIbβ3 integrin engagement in thrombin‐stimulated plateletsFEBS Letters, 1997
- Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphateScience, 1997
- Phosphoinositide 3-Kinase γ and p85/Phosphoinositide 3-Kinase in PlateletsJournal of Biological Chemistry, 1996
- Phosphoinositide 3-Kinase Inhibition Spares Actin Assembly in Activating Platelets but Reverses Platelet AggregationJournal of Biological Chemistry, 1995
- Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated plateletsBiochemical Journal, 1994
- Evidence that activation of platelet calpain is induced as a consequence of binding of adhesive ligand to the integrin, glycoprotein IIb-IIIa.The Journal of cell biology, 1993
- Accumulation of PtdIns(3,4)P2 and PtdIns(3,4,5)P3 in thrombin-stimulated platelets. Different sensitivities to Ca2+ or functional integrinBiochemical Journal, 1992