Thermoregulatory responses of dogs after alteration of peripheral sensitivity

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Abstract
Topically applied pharmacologic agents were used to alter skin sensitivity of unanesthetized dogs subjected to rapid changes in thermal state. The anesthetic pramoxine hydrochloride was utilized to depress peripheral sensitivity; menthol was used to enhance it. Application of these agents produced shifts in specific skin temperature at which activation and suppression of both panting and shivering occur. These changes were interpreted as indicating peripheral mediation in control of thermoregulatory end mechanisms. Both substances exhibited a greater effect on thermoregulatory responses to cooling than to heating. Consequently, one may infer that the peripheral cold-fiber effect exerts a greater influence on thermoregulatory end mechanisms than does the warm-fiber effect.

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