Interaction of the Protein Kinase Raf-1 with 14-3-3 Proteins
- 7 October 1994
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 266 (5182) , 126-129
- https://doi.org/10.1126/science.7939632
Abstract
Members of a family of highly conserved proteins, termed 14-3-3 proteins, were found by several experimental approaches to associate with Raf-1, a central component of a key signal transduction pathway. Optimal complex formation required the amino-terminal regulatory domain of Raf-1. The association of 14-3-3 proteins and Raf-1 was not substantially affected by the activation state of Raf.Keywords
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