Intrazelluläre Verteilung von Hexokinase und ATP in der Leber alloxandiabetischer Mäuse
- 1 January 1962
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 328 (Jahresband) , 164-172
- https://doi.org/10.1515/bchm2.1962.328.1.164
Abstract
In short term diabetes, the hexokinase activity of liver homogenates and its intracellular distribution are normal. Most of the activity is in the cytoplasm. The concentrations of ATP and ADP and their intracellular distribution in the liver are normal. The mito-chondrial fraction is not decreased in the diabetic liver. The succinate dehydrogenase activity is increased 4 days after the alloxan injection and is normal again after 3 weeks. Mitochondria from diabetic livers exhibit a slightly increased oxygen uptake, but a normal P/O ratio. It is proposed that the inhibition of glucose phosphorylation in diabetes is caused by a disturbance of the further reactions of glucose 6-phos-phate.Keywords
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