AN EMPIRICAL STUDY TO ASCERTAIN THE VALUE OF MEASUREMENT OF NUCLEAR SIZE AND ECCENTRICITY IN ASSESSING FUNCTIONAL CHANGES IN THE CELLS OF LANGERHANS’ ISLETS

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Abstract
An investigation was carried out to compare the value of determinations of nuclear size and nuclear eccentricity in the cells of Langerhans'' islets, and a negative correlation was found between changes in size and in eccentricity. The usefulness of these methods in assessing changes in nuclear activity in [beta]- and [alpha] -cells was also examined, and it was found that the standard error of the single determination was smaller for determination of size than for determination of eccentricity. A size determination as a rule gave evidence of a change In nuclear activity sooner than an eccentricity determination, and in most cases the significance figures for the deviations were also higher. One exception to this rule was observed, however.

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