The inhibition of phosphoglucomutase by beryllium

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Abstract
The inhibition of phosphoglucomutase by Be has been examined. Inhibition by Be does not occur unless a complex-forming agent such as cysteine or imidazole is present. It is therefore similar to activation by Mg. The inhibition is progressive and the rate follows first-order kinetics, which may be defined by a bimolecular rate constant. In the presence of Mg the rate of inhibition is less. By using a fixed time for inhibition competition between Be and Mg may be demonstrated. After inhibition has taken place, the addition of Mg does not reverse it.