The inhibition of enzymes by beryllium
- 31 December 1965
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 98 (1) , 94-99
- https://doi.org/10.1042/bj0980094
Abstract
The action of beryllium on the following enzymes has been examined: alkaline phosphatase (Escherichia coli and kidney), acid phosphatase, phosphoprotein phosphatase, apyrase (potato), adenosine triphosphatase (liver nuclei, liver mitochondria, brain miscrosomes), glucose 6-phosphatase, polysaccharide phosphorylases a and b, phosphoglucomutase, hexokinase, phosphoglyceromutase, ribonuclease, A-esterase (rabbit serum), cholinesterase (horse serum), chymotrypsin. Alkaline phosphatase and phosphoglucomutase are inhibited by 1[mu]M-beryllium sulfate whereas the other enzymes are largely unaffected by 1 m[image]-beryllium sulfate. Possible mechanisms for the inhibition of phosphoglucomutase and alkaline phosphatase are discussed.This publication has 55 references indexed in Scilit:
- THE AMINO ACID SEQUENCE OF A TETRADECAPEPTIDE CONTAINING THE REACTIVE SERINE IN E. COLI ALKALINE PHOSPHATASEProceedings of the National Academy of Sciences, 1963
- PHOSPHATE INCORPORATION INTO ALKALINE PHOSPHATASE OF E. COLIProceedings of the National Academy of Sciences, 1961
- Further studies on the incorporation of inorganic phosphate into calf-intestinal alkaline phosphataseBiochimica et Biophysica Acta, 1961
- Properties of crystalline hexokinase from yeast II. Studies on ATP-enzyme interactionArchives of Biochemistry and Biophysics, 1961
- A fine-structure genetic and chemical study of the enzyme alkaline phosphatase of E. Coli I. Purification and characterization of alkaline phosphataseBiochimica et Biophysica Acta, 1960
- Metal-ion specificity in the activation of enolaseArchives of Biochemistry and Biophysics, 1955
- Serum esterases. 1. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determinationBiochemical Journal, 1953
- Mango Grafting in Eight WeeksScience, 1951
- Epidemiology of beryllium intoxication.1951
- Chromatographic studies on nucleic acids. 2. The quantitative analysis of ribonucleic acidsBiochemical Journal, 1950