Synthesis of the nonatetracontapeptide corresponding to the entire amino acid sequence of thymopoietin I and its effect on the low E-rosette-forming cells of a uremic patient.

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Abstract
The nonatetracontapeptide corresponding to the entire amino acid sequence of thymopoietin I was synthesized by successive azide condensation of 7 fragments: Boc-(36-4)-NHNH2; Boc-(30-35)-NHNH2; Boc-(25-29)-NHNH2; Boc-(20-24)-NHNH2; Boc-(16-19)-NHNH2; Boc-(8-15) NHNH2; and Boc-(1-7)-NHNH2 with H-(42-49)-OBzl. The deprotection of the protected nonatetracontapeptide was achieved by treatment with HF in the presence of anisole-thioanisole-m-cresol. An increase of E-rosette-forming cells was obtained after incubation of peripheral blood from a uremic patient with the synthetic nonatetracontapeptide at the dose of 1 .mu.g/ml.